Evaluation of Drug Serum Protein Binding
by Fluorophore-sbp

Fluorophore-sbp reagent and the Fluorosome® Solution FS-1 provides a rapid means to determine the binding affinity of drugs to specific serum proteins.

The binding affinity, KD , of a drug to two major serum proteins using Fluorophore-sbp reagent.

The distribution and bioavailability of drugs can be strongly influenced by their binding to serum proteins. Serum proteins function in the circulatory system as carriers of drugs as well as acting as drug reservoirs. The ability to characterize the extent of binding of drug candidates to serum proteins provides valuable information as to the state of the drugs in the circulatory system.

The Fluorosome® Company offers Fluorophore-sbp reagent for two major serum proteins, serum albumin (SA) and alpha-1-acid glycoprotein (AGP). These reagents in conjunction with the Fluorosome® Solution FS-1 provide a rapid and sensitive means to quantitate the binding of drugs to serum proteins.