Pharmacology & Pharmacokinetics

Our experienced staff of pharmacologists provides comprehensive drug discovery and evaluation services to virtual, small and large pharmaceutical companies.


Our staff specializes in the in vitro and in vivo testing of new compounds, ADME (absorption, distribution, metabolism and elimination) in rodents (non-GLP), toxicology, and pharmacology methods development. Our pharmacology department also participates in customized research programs by contract with pharmaceutical companies, and engages in small business grant supported projects.
Master agreements and pharmaceutical development agreements are negotiated to suit the intellectual property needs of the customer.

We offer:

Pharmacology:

In vitro pharmacodynamic analysis of potential therapeutics:

  • Isolated tissue studies
  • Isolated organ preparations

    In vivo topical and systemic drug pharmacodynamic analysis:

  • Anti-inflammatories
  • Antibacterials
  • Bladder motility
  • Topical anesthetics
  • Erectile function
  • Intestinal motility
  • Blood pressure (direct measurement) and heart rate models
  • Effect of drugs on QT-interval
  • Acute and chronic toxicity
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    Pharmacokinetics:

    New! The Fluorosome™ Technique for high throughput drug permeability studies.

  • Methods development for detection of novel agents

    Basic pharmacokinetics in rodents

  • half-life and volume of distribution following IP, SC, PO, and IV administration

    In vivo and in vitro drug metabolism

  • Metabolism by liver microsomes and S9 liver fractions (human and preclinical species)
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    Facilities:

  • GLSynthesis Inc. offices and laboratories are located in the Massachusetts Biotechnology Research Park in Worcester, MA
  • Fully equipped pharmacology laboratory, including computer integrated Grass Polygraph Systems (4 Model 7 poly-graphs, 1 TBRS2 system and 1 SLS4 system), isolated organ and tissue bath preparations, surgical suite
  • Full animal husbandry facilities
  • Pharmacological and statistical acquisition and analysis software.
  • Fully equipped pharmacokinetic analysis laboratory, including automated HPLC system, manual HPLC systems and speed vac for sample preparation.
  • Pharmacokinetic analysis software
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    For further information or quotation, please contact the marketing manager or email to glsyn@glsynthesis.com.