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February 2012. The Fluorosome Company, a division of GLSynthesis, has published a paper describing the results of p-glycoprotein assays using Fluorosome-trans-pgp, the first active transport protein to be embedded in a lipid membrane bilayer in functional form.

July 2010. GLSynthesis scientists awarded a phase II SBIR grant to develop Ap4A analogs as antiplatelet drugs.

May 2010. Scientists from GLSynthesis (Wei-Chu Xu, Sofya Dvoskin, Neal Brown, Joseph Gambino and George Wright) and Istituto Genetica Molecolare, CNR, Pavia, Italy (Andrea Lossani, Andrea Torti and Federico Focher) will present a poster entitled “Clostridium difficile DNA polymerase IIIC: cloning, purification and analysis of specific inhibitors” at the meeting “Evolving DNA Polymerases: Chemistry meets Biology”, Monte Verita, Switzerland, May 9-14, 2010.

March 2010. GLSynthesis scientists awarded a competing renewal phase II SBIR grant to complete preclinical studies of a drug to treat Clostridium difficile diarrhea.

September 2009. Scientists from GLSynthesis (Sofya Dvoskin, George Wright) and Latitude Pharmaceuticals, San Diego, CA, (Andrew Chen, Hau Dang, Hailang Chen) presented a poster entitled "AU-FQ antibacterial compounds: activity against Gram+ organisms and development of an emulsion formulation" at the 49th Interscience Conference on Antimicrobial Agents and Chemotherapy, San Francisco, CA, September 12-15, 2009.

November 2008. Scientists from GLSynthesis (Donald L. Melchior, George E. Wright and Steven E. Wright) and the University of Guelph, Guelph, Ontario (Frances J. Sharom and Rohngua Lui), presented a poster entitled "Reconstituted P-glycoprotein in Fluorosome® lipid bilayer vesicles - basis for an in vitro P-glycoprotein assay.” at the abcam sponsored “Mulitdrug Resistance and ABC Transporters Conference” in Baltimore, Maryland, November 5, 2008.

September 2008. Scientists from GLSynthesis (George Wright) and the Italian National Research Council (Andrea Lossani, Andrea Torti and Federico Focher) and San Matteo Hospital (Simona Gatti) in Pavia, Italy, present a poster entitled "Cloning and characterization of thymidine kinase and uridine-cytidine kinase from Entamoeba histolytica. Search for specific inhibitors." at the meeting of the Federazione Italiana Scienze della Vita, Riva del Garda, Italy, September 24-27, 2008.

March 2008. GLSynthesis and UMass Medical School present results of work on platelet antiaggregation activity of Ap4A and related compounds. Poster presented at American College of Cardiology Meeting, by H. Chang, I.B. Yanachkov, A.D. Michelson, G.E. Wright and A.L. Frelinger. "Diadenosine P1,P4-tetraphosphate and Its Tetraphosphonate Derivatives Synergistically Inhibit Platelet Activation via Both P2Y1 and P2Y12". Chicago, IL, March 29-April, 2008.

January 2008. GLSynthesis receives phase II small business grant from NIH to develop Fluorosome® active transport model. GLSynthesis has been awarded a 2 year phase II small business (SBIR) grant from the National Institute of General Medical Sciences (NIGMS), an institute of the National Institutes of Health (NIH) to continue development of a Fluorosome-based assay for p-glycoprotein. P-glycoprotein (pgp, MDR1) is the major mammalian drug transport protein found in cell membranes. It is responsible for efflux of many drugs from tissues, e.g. intestines and blood-brain barrier, and is a major source of antitumor drug resistance.

September 2007. GLSynthesis and Microbiotix present work on antibacterial prodrugs. Poster presented at International Congress on Antimicrobial Agents and Chemotherapy. G.E. Wright, S. Dvoskin, M. Yanachkova, W. Xu, I.B. Yanachkov, E. Dix, N.C. Brown, M.M. Butler, L. Kustigian and T. Bowlin, Prodrug Delivery of AU-FQ Antibacterial Compounds., Chicago, September 17-20, 2007.

June 2007. GLSynthesis establishes manufacturing plant in Zhianjiagang, near Shanghai, China. A full range of chemical product development, analysis and production is available at this plant. See Production Facilities for details.

June 2006. GLSynthesis awarded U.S. Patent 7,060,292, Lipid Structures and Uses Thereof, Inventors: D. Melchior and A. Carruthers.

August 2005. GLSynthesis awarded U.S. Patent 6,926,763, Purine and Isosteric Antibacterial Compounds, inventors: G.E. Wright, W.-C. Xu and N.C. Brown.


Recent Publications

D.L. Melchior, F.J. Sharom, R. Evers, G.E. Wright, J.W.K. Chu, S.E. Wright, X. Chu and J. Yabut. Determining P-glycoprotein-drug interactions: evaluation of reconstituted P-glycoprotein by a liposomal system and LLC-MDR1 polarized cell monolayers. J. Pharm. Tox. Meth. 65, 64-74 (2012).

S. Dvoskin, W.-C. Xu, N.C. Brown, I.B. Yanachkov, M. Yanachkova and G.E. Wright. A novel agent effective against infection with Clostridium difficile. Antimicr. Agents Chemother. 56, 1624-1626 (2012).

A. Torti, A. Lossani, L. Savi, F. Focher, G.E. Wright, N.C. Brown and W.-C. Xu. Cloning and expression of DNA polymerase IIIC of Clostridium difficile: basis for activity of antibacterial compounds, Curr. Enz. Inh. 7, 147-153 (2011).

W-C. Xu, G.E. Wright, N.C. Brown, Z.-y.Long, C. Zhi, S. Dvoskin, J.J. Gambino, M.H. Barnes and M.M. Butler. 7-Alkyl-N2-Substituted-3-deazaguanines. Synthesis, DNA polymerase III inhibition and antibacterial activity. Bioorg. Med. Chem. Lett. 21, 4197-4202 (2011).

I.B. Yanachkov, E. J. Dix, M.I. Yanachkova and G.E. Wright. P1,P2-Diimidazolyl derivatives of pyrophosphate and bis-phosphonates – synthesis, properties, and use in preparation of dinucleoside tetraphosphates and analogs. Org. Biomol. Chem. 9, 730-738 (2011).

H.Chang, I.B. Yanachkov, A.D. Michelson, Y.-F. Li, M.R. Barnard, G.E. Wright and A.L. Frelinger III. Agonist and Antagonist Effects of Diadenosine Tetraphosphate, a Platelet Dense Granule Constituent, on Platelet P2Y1, P2Y12 and P2X1 Receptors. Thromb. Res., 125, 159-165 (2010).

A. Lossani, A. Torti, S. Gatti, A. Bruno, R. Maserati, G.E. Wright and F. Focher. Thymidine kinase and uridine-cytidine kinase from Entamoeba histolytica. Cloning, characterization and search for specific inhibitors. Parasitol. 136, 595-602 (2009).

B.M. Gebhardt, F. Focher, R. Eberle, A. Manikowski and G.E. Wright. Effects of Combinations of Antiviral Drugs on Herpes Simplex Encephalitis. Drug Design, Development and Therapy. 3, 289-294 (2009).

D. Tabatadze, P. Zamecnik, I. Yanachkov, G. Wright, K. Pierson, S. Zhang , A. Bogdanov Jr. and V. Metelev. A Novel Thymidine Phosphoramidite Synthon for Incorporation of Internucleoside Phosphate Linkers During Automated Oligodeoxynucleotide Synthesis. Nucleos. Nucleot. Nucl. Acids 27, 157-172 (2008).

M.M. Butler and G.E. Wright, A Method to Assay Inhibitors of DNA Polymerase III Activity. in New Antibiotic Targets, S. Champney, Ed., Humana Press Inc., Totowa NJ, 2008.

M.M. Butler, W.A. LaMarr, K.A. Foster, M.H. Barnes, D.J. Skow, P.T. Lyden, C. Zhi, N.C. Brown, G.E. Wright and T.L. Bowlin. Antibacterial Activity and Mechanism of Action of a Novel Anilinouracil:Fluoroquinolone Hybrid Compound. Antimicrob. Agents Chemother. 51, 119-127 (2007).

F. Focher, A. Lossani, A. Verri, S. Spadari, A. Maioli, J.J. Gambino, G.E. Wright, R. Eberle, D.H. Black, P. Medveczky, M. Medveczky and D. Shugar. Sensitivity of Monkey B Virus (Cercopithecine herpesvirus 1, BV) to Antiviral Drugs. Role of Thymidine Kinase in Antiviral Activity of Substrate Analogs and Acyclonucleosides. Amtimicrob. Agents Chemother. 51, 2028-2034 (2007).

C. Zhi, Z.-Y. Long, A. Manikowski, J. Comstock, W.-C. Xu, N.C. Brown, P.M. Tarantino, Jr., K.A. Holm, E.J. Dix, G.E. Wright, M.H. Barnes, M.M. Butler, K.A. Foster, W.A. LaMarr, B. Bachand, R. Bethell, C. Cadilhac, S. Charron, S. Lamothe, I. Motorina, and R. Storer. Hybrid Antibacterials. DNA polymerase:topoisomerase inhibitors. J. Med. Chem. 49, 1455-1465 (2006).


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